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Publications

2024

  1. Evaluation of the activity of cardiac glycosides on RORγ and RORγT nuclear receptors. Karwaciak I, Pastwińska J, Sałkowska A, Bachorz RA, Ratajewski M. Arch Biochem Biophys. 2024 Sep;759:110085. doi: 10.1016/j.abb.2024.110085. Epub 2024 Jul 4.
  2. α-Hemolysin from Staphylococcus aureus Changes the Epigenetic Landscape of Th17 Cells. Pastwińska J, Karwaciak I, Karaś K, Sałkowska A, Chałaśkiewicz K, Strapagiel D, Sobalska-Kwapis M, Dastych J, Ratajewski M. Immunohorizons. 2024 Sep 1;8(9):606-621. doi: 10.4049/immunohorizons.2400061.
  3. Epigenetic regulation of the human GDAP1 gene. Karaś K, Pastwińska J, Sałkowska A, Karwaciak I, Ratajewski M. Biochem Biophys Rep. 2024 Sep 19;40:101827. doi: 10.1016/j.bbrep.2024.101827.
  4. QSPRmodeler – An open source application for molecular predictive analytics. Bachorz RA, Nowak D, Ratajewski M. Front. Bioinform. 2024 Sep 24; 4:1441024. doi: 10.3389/fbinf.2024.1441024

2023

  1. Anti-hepatocellular carcinoma activity of the cyclin-dependent kinase inhibitor AT7519. Karaś K, Karwaciak I, Chałaśkiewicz K, Sałkowska A, Pastwińska J, Bachorz RA, Ratajewski M. Biomed Pharmacother. 2023 Aug;164:115002. doi: 10.1016/j.biopha.2023.115002. Epub 2023 Jun 11.
  2. Trichostatin A inhibits expression of the human SLC2A5 gene via SNAI1/SNAI2 transcription factors and sensitizes colon cancer cells to platinum compounds. Chałaśkiewicz K, Karaś K, Zakłos-Szyda M, Karwaciak I, Pastwińska J, Koziołkiewicz M, Ratajewski M. Eur J Pharmacol. 2023 Jun 15;949:175728. doi: 10.1016/j.ejphar.2023.175728. Epub 2023 Apr 14
  3. The paradox of autoimmunity and autoinflammation in inherited neutrophil disorders – in search of common patterns. Krzyzanowski D, Oszer A, Madzio J, Zdunek M, Kolodrubiec J, Urbanski B, Mlynarski W, Janczar S. Front Immunol. 2023 Jun 7;14:1128581. doi: 10.3389/fimmu.2023.1128581. eCollection 2023.
  4. Mesalazine-PAMAM Nanoparticles for Transporter-Independent Intracellular Drug Delivery: Cellular Uptake and Anti-Inflammatory Activity. Gorzkiewicz M, Marcinkowska M, Studzian M, Karwaciak I, Pulaski L, Klajnert-Maculewicz B. Int J Nanomedicine. 2023 Apr 24;18:2109-2126. doi: 10.2147/IJN.S390763. eCollection 2023.
  5. RORγT agonists as immune modulators in anticancer therapy. Pastwińska J, Karwaciak I, Karaś K, Bachorz RA, Ratajewski M. Biochim Biophys Acta Rev Cancer . 2023 Nov;1878(6):189021. doi: 10.1016/j.bbcan.2023.189021.
  6. The application of machine learning methods to the prediction of novel ligands for ROR γ/ROR γ T receptors. Bachorz RA, Pastwińska J, Nowak D, Karaś K, Karwaciak I, Ratajewski M. Comput Struct Biotechnol J. 2023 Oct 29:21:5491-5505. doi: 10.1016/j.csbj.2023.10.021.

2022

  1. Targeting EGFR in melanoma – The sea of possibilities to overcome drug resistance. Pastwińska J, Karaś K, Karwaciak I, Ratajewski M. Biochim Biophys Acta Rev Cancer. 2022 Jul;1877(4):188754. doi: 10.1016/j.bbcan.2022.188754. Epub 2022 Jun 27.
  2. Chlorpromazine, a Clinically Approved Drug, Inhibits SARS-CoV-2 Nucleocapsid-Mediated Induction of IL-6 in Human Monocytes. Karwaciak I, Karaś K, Sałkowska A, Pastwińska J, Ratajewski M. Molecules. 2022 Jun 7;27(12):3651. doi: 10.3390/molecules27123651
  3. Identification of Corosolic and Oleanolic Acids as Molecules Antagonizing the Human RORγT Nuclear Receptor Using the Calculated Fingerprints of the Molecular Similarity. Pastwińska J, Karaś K, Sałkowska A, Karwaciak I, Chałaśkiewicz K, Wojtczak BA, Bachorz RA, Ratajewski M. Int J Mol Sci. 2022 Feb 8;23(3):1906. doi: 10.3390/ijms23031906.
  4. Hypoxia modulates human mast cell adhesion to hyaluronic acid. Pastwińska J, Walczak-Drzewiecka A, Kozłowska E, Harunari E, Ratajewski M, Dastych J. Immunol Res. 2022 Apr;70(2):152-160. doi: 10.1007/s12026-021-09228-x. Epub 2021 Nov 17.
  5. Cyanobacterial cell-wall components as emerging environmental toxicants – detection and holistic monitoring by cellular signaling biosensors. Gągała-Borowska I, Karwaciak I, Jaros D, Ratajewski M, Kokociński M, Jurczak T, Remlein B, Rudnicka K, Pułaski Ł, Mankiewicz-Boczek J. Sci Total Environ. 2022 Feb 10;807(Pt 2):150645. doi: 10.1016/j.scitotenv.2021.150645. Epub 2021 Oct 9.

2021

  1. Phenolics-Rich Extracts of Dietary Plants as Regulators of Fructose Uptake in Caco-2 Cells via GLUT5 Involvement. Zakłos-Szyda M, Pietrzyk N, Kowalska-Baron A, Nowak A, Chałaśkiewicz K, Ratajewski M, Budryn G, Koziołkiewicz M. Molecules. 2021 Aug 5;26(16):4745. doi: 10.3390/molecules26164745.
  2. Targeting SIRT2 Sensitizes Melanoma Cells to Cisplatin via an EGFR-Dependent Mechanism. Karwaciak I, Sałkowska A, Karaś K, Dastych J, Ratajewski M. Int J Mol Sci. 2021 May 10;22(9):5034. doi: 10.3390/ijms22095034.
  3. Recombinant immunotoxin targeting GPC3 is cytotoxic to H446 small cell lung cancer cells. Rodakowska E, Walczak-Drzewiecka A, Borowiec M, Gorzkiewicz M, Grzesik J, Ratajewski M, Rozanski M, Dastych J, Ginalski K, Rychlewski L. Oncol Lett. 2021 Mar;21(3):222. doi: 10.3892/ol.2021.12483. Epub 2021 Jan 21.
  4. Nucleocapsid and Spike Proteins of the Coronavirus SARS-CoV-2 Induce IL6 in Monocytes and Macrophages-Potential Implications for Cytokine Storm Syndrome. Karwaciak I, Sałkowska A, Karaś K, Dastych J, Ratajewski M. Vaccines (Basel). 2021 Jan 15;9(1):54. doi: 10.3390/vaccines9010054.
  5. Differential Action of Silver Nanoparticles on ABCB1 (MDR1) and ABCC1 (MRP1) Activity in Mammalian Cell Lines. Krzyzanowski D, Kruszewski M, Grzelak A. Materials (Basel). 2021 Jun 18;14(12):3383. doi: 10.3390/ma14123383.
  6. Neutrophil Elastase Defects in Congenital Neutropenia. Rydzynska Z, Pawlik B, Krzyzanowski D, Mlynarski W, Madzio J. Front Immunol. 2021 Apr 22;12:653932. doi: 10.3389/fimmu.2021.653932. eCollection 2021.
  7. Do Mast Cells Contribute to the Antifungal Host Defense? Żelechowska P, Pastwińska J, Brzezińska-Błaszczyk E, Agier J. Cells. 2021 Sep 22;10(10):2510. doi: 10.3390/cells10102510.

2020

  1. SARS-CoV-2 Proteins Induce IFNG in Th1 Lymphocytes Generated from CD4+ Cells from Healthy, Unexposed Polish Donors. Sałkowska A, Karwaciak I, Karaś K, Dastych J, Ratajewski M. Vaccines (Basel). 2020 Nov 12;8(4):673. doi: 10.3390/vaccines8040673.
  2. Anticancer Imidazoacridinone C-1311 is Effective in Androgen-Dependent and Androgen-Independent Prostate Cancer Cells. Niemira M, Borowa-Mazgaj B, Bader SB, Moszyńska A, Ratajewski M, Karaś K, Kwaśniewski M, Krętowski A, Mazerska Z, Hammond EM, Skwarska A. Biomedicines. 2020 Aug 19;8(9):292. doi: 10.3390/biomedicines8090292.
  3. Identification of Novel Molecular Markers of Human Th17 Cells. Sałkowska A, Karaś K, Karwaciak I, Walczak-Drzewiecka A, Krawczyk M, Sobalska-Kwapis M, Dastych J, Ratajewski M. Cells. 2020 Jul 3;9(7):1611. doi: 10.3390/cells9071611.
  4. Hypoxia regulates human mast cell adhesion to fibronectin via the PI3K/AKT signaling pathway. Pastwińska J, Walczak-Drzewiecka A, Łukasiak M, Ratajewski M, Dastych J. Cell Adh Migr. 2020 Dec;14(1):106-117. doi: 10.1080/19336918.2020.1764690
  5. Cardiac glycosides with target at direct and indirect interactions with nuclear receptors. Karaś K, Sałkowska A, Dastych J, Bachorz RA, Ratajewski M. Biomed Pharmacother. 2020 Jul;127:110106. doi: 10.1016/j.biopha.2020.110106. Epub 2020 Apr 2.

2019

  1. The Dichotomous Nature of AZ5104 (an EGFR Inhibitor) Towards RORγ and RORγT. Karaś K, Sałkowska A, Karwaciak I, Walczak-Drzewiecka A, Dastych J, Bachorz RA, Ratajewski M. Int J Mol Sci. 2019 Nov 17;20(22):5780. doi: 10.3390/ijms20225780.
  2. SIRT2 Contributes to the Resistance of Melanoma Cells to the Multikinase Inhibitor Dasatinib. Karwaciak I, Sałkowska A, Karaś K, Sobalska-Kwapis M, Walczak-Drzewiecka A, Pułaski Ł, Strapagiel D, Dastych J, Ratajewski M. Cancers (Basel). 2019 May 14;11(5):673. doi: 10.3390/cancers11050673.
  3. Digoxin, an Overlooked Agonist of RORγ/RORγT. Karaś K, Sałkowska A, Sobalska-Kwapis M, Walczak-Drzewiecka A, Strapagiel D, Dastych J, Bachorz RA, Ratajewski M. Front Pharmacol. 2019 Jan 7;9:1460. doi: 10.3389/fphar.2018.01460. eCollection 2018.
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