Medicinal Chemistry

Chemistry of nucleosides, nucleotides and nucleic acids for molecular technologies as biotherapeutics, nanomaterials and molecular probes:

• Synthesis, studies of physicochemical and biological properties of modified nucleosides, nucleotides and DNA/RNA-oligonucleotides containing boron clusters and their complexes with metals
• The relationship between structure and physicochemical and biological properties of modified DNA/RNA-oligonucleotides and their components
• Modified nucleic acids as new materials for nanotechnology and other molecular technologies, biotherapeutics and molecular probes
• Nucleoside derivatives with antiviral, antitumor and purinergic receptor modulating activity
• Boron carriers for BNCT of tumors