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Publications

List of selected publications

Selected papers 2019-2021

Rok 2023
Daniel Baranowski, Adam Mieczkowski, Damian Trzybinski, Krzysztof Wozniak, Katarzyna Bednarska-Szczepaniak, Zofia Gdaniec, Zbigniew J. Lesnikowski, Insights into molecular structure of adenosine-boron cluster conjugates and theirs phenyl isosters as adenosine receptor ligands: Nuclear magnetic resonance, crystallographic and computational studies. J. Mol. Struct., 2023, 1274, 134588. doi.org/10.1016/j.molstruc.2022.134588

Krzysztof Smiałkowski, Carla Sardo, Zbigniew J. Lesnikowski, Metallacarborane Synthons for Molecular Construction— Oligofunctionalization of Cobalt Bis(1,2-dicarbollide) on Boron and Carbon Atoms with Extendable Ligands. Molecules, 2023, 28, 4118; doi.org/10.3390/molecules28104118

Rok 2022
Katarzyna Bednarska-Szczepaniak, Katarzyna Dziedzic-Kocurek, Ewelina Przelazły, Jan Stanek and Zbigniew J. Leśnikowski, Intramolecular rotations and electronic states of iron in the iron bis(dicarbollide) complex Fe[(C2B9H11)2] studied by a 57Fe nuclear probe and computational methods. Chem. Commun., 2022, 58, 391-394, DOI: 10.1039/D1CC05111C.

Joanna Bojarska, Martin Breza, Milan Remko, Paweł Borowiecki, Andrzej Fruziński, Izabela D. Madura, Krzysztof Kaczmarek, Zbigniew Leśnikowski, Agata Kraj, Piotr Zielenkiewicz and Wojciech M. Wolf, Supramolecular synthon hierarchy in cyclopropyl-containing peptide-derived compounds, CrystEngCom, 2022, DOI: 10.1039/d2ce01231f

Rok 2021
Storm Hassell-Hart, Sarah Picaud, Raphael Lengacher, Joshua Csucker, Regis Millet, Gilles Gasser, Roger Alberto, Hannah Maple, Robert Felix, Zbigniew J. Leśnikowski, Helen J. S. Stewart, Timothy J. Chevassut, Simon Morley, Panagis Filippakopoulos, John Spencer,
Probing BRD Inhibition Substituent Effects in Bulky Analogues of (+)-JQ1.
Helvetica Chimica Acta., 2021, 104, e2000214, DOI: 10.1002/hlca.202000214

Damian Kaniowski, Katarzyna Ebenryter-Olbińska, Katarzyna Kulik,
Justyna Suwara, Wojciech Cypryk, Agata Jakóbik-Kolon, Zbigniew Leśnikowski, Barbara Nawrot
Composites of nucleic acids and boron clusters (C2B10H12) as functional nanoparticles for downregulation of EGFR oncogene in cancer cells
International Journal of Molecular Sciences, 2021, 22, 4863. https://doi.org/10.3390/ijms22094863

David Kodr, Cansu Pinar Yenice, Anna Simonova, Dijana Pavlović Saftić, Radek Pohl, Veronika Sýkorová, Mayreli Ortiz, Luděk Havran, Miroslav Fojta, Zbigniew J. Lesnikowski, Ciara K. O’Sullivan, and Michal Hocek
Carborane- or Metallacarborane-Linked Nucleotides for Redox Labelling. Orthogonal Multipotential Coding of all Four DNA Bases for Electrochemical Analysis and Sequencing
Journal of American Chemical Society, 2021, 143, 7124-7134. https://doi.org/10.1021/jacs.1c02222

Katarzyna Bednarska-Szczepaniak, Adam Mieczkowski, Aleksandra Kierozalska, Dijana Saftić, Konrad Głąbała, Tomasz Przygodzki, Lidia Stańczyk, Kamil Karolczak, Cezary Watała, Harsha Rao, Zhan-Guo Gao, Kenneth A. Jacobson, and Zbigniew J. Leśnikowski, Synthesis and evaluation of adenosine derivatives as A1, A2A, A2B and A3 adenosine receptor ligands containing boron clusters as phenyl isosteres and selective A3 agonists, European Journal of Medicinal Chemistry, 2021, 223, 113607. https://doi.org/10.1016/j.ejmech.2021.113607

Sedlák, D., Wilson, T.A., Tjarks,W., Radomska, H.S., Wang, H., Kolla, J.N., Leśnikowski, Z.J., Špičáková, A., Ali, T., Ishita, K., Rakotondraibe, L.H., Vibhute, S., Wang, D., Anzenbacher, P., Bennett, C., Bartunek, P., Coss, C.C., Structure−Activity Relationship of para-Carborane Selective Estrogen Receptor β Agonists. Journal of Medicinal Chemistry., 2021, 64, 9330−9353.

Bednarska-Szczepaniak K, Przelazły E, Kania KD, Szwed M, Litecká M, Grűner B, Leśnikowski ZJ. Interaction of Adenosine, Modified Using Carborane Clusters, with Ovarian Cancer Cells: A New Anticancer Approach against Chemoresistance. Cancers (Basel) 2021, 15:3855. 10.3390/cancers13153855

Paradowska E, Studzińska M, Jabłońska A, Lozovski V, Rusinchuk N, Mukha I, Vitiuk N, Leśnikowski ZJ. Antiviral Effect of Nonfunctionalized Gold Nanoparticles against Herpes Simplex Virus Type-1 (HSV-1) and Possible Contribution of Near-Field Interaction Mechanism. Molecules, 2021, 26:5960. 10.3390/molecules26195960.

Rok 2020
Dijana Saftić, Mirosława Studzińska, Edyta Paradowska, Ivo Piantanida, Goran Baranović, Magdalena Białek-Pietras and Zbigniew J. Leśnikowski
Comparative study of the effects of ortho-, meta- and para-carboranes (C2B10H12) on the physicochemical properties, cytotoxicity and antiviral activity of uridine and 2’-deoxyuridine boron cluster conjugate.
Bioorganic Chemistry, 2020, 94, 103466. doi.org/10.1016/j.bioorg.2019.103466

Damian Kaniowski, Katarzyna Ebenryter-Olbinska, Katarzyna Kulik, Slawomir Janczak, Anna Maciaszek, Katarzyna Bednarska-Szczepaniak, Barbara Nawrot and Zbigniew Lesnikowski
Boron Clusters as a Platform for New Materials: Composites of Nucleic Acids and Oligofunctionalized Carboranes (C2B10H12) and their Assembly into Functional Nanoparticles Nanoscale, 2020, 12, 103–114 DOI: 10.1039/C9NR06550D

Damian Kaniowski, Katarzyna Kulik, Katarzyna Ebenryter-Olbińska, Ewelina Wielgus,
Zbigniew Leśnikowski and Barbara Nawrot
Metallacarborane Complex Boosts the Rate of DNA Oligonucleotide Hydrolysis in the Reaction Catalyzed by Snake Venom Phosphodiesterase
Biomolecules 2020, 10, 718; doi:10.3390/biom10050718.

Agnieszka Jabłonska, Anna S. Swierzko, Mirosława Studzinska, Patrycja Suski, Jarosław Kalinka, Zbigniew J. Lesnikowski, Maciej Cedzynski, Edyta Paradowska
Insight into the expression of RIG-I-like receptors in human third trimester placentas following ex vivo cytomegalovirus or vesicular stomatitis virus infection
Molecular Immunology, 2020, 126, 143–152.

Zbigniew J. Leśnikowski
What are the current challenges with the application of boron clusters to drug design?
Expert Opinion on Drug Discovery, 2020, DOI: 10.1080/17460441.2021.1867531

Rok 2019
P. Brennecke, D. Rasina, O. Aubi, …. Z. Lesnikowski and forty other co-authors
EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology
SLAS Discovery, 2019, 1–16.

Daria Różycka, Zbigniew J. Lesnikowski, Agnieszka B. Olejniczak
Synthesis of boron cluster analogs of penicillin and their antibacterial activity
Journal of Organometallic Chemistry, 2019, 881 19e24

Adam Mieczkowski, Aleksandra Kierozalska, Magdalena Białek-Pietras, Tomasz M. Goszczyński, Slawomir Janczak, Agnieszka B. Olejniczak, Mirosława Studzińska, Edyta Paradowska and Zbigniew J. Leśnikowski
Comparative study of inorganic, boron-rich cluster and organic, phenyl adenosine modifications: Synthesis and properties
Future Medicinal Chemistry, 2019,11, 1267-1284. doi: 10.4155/fmc-2018-0517

Carla Sardo, Sławomir Janczak and Zbigniew J. Leśniowski
Unusual resistance of cobalt bis dicarbollide phosphate and phosphorothioate bridged esters towards alkaline hydrolysis: The “metallacarborane effect“
Journal of Organometallic Chemistry, 2019, 896, 70-76.

Masahito Mochizuki, Shinichi Sato, Syifa Asatyas, Zbigniew J. Lesnikowski, Tomohiro Hayashi and Hiroyuki Nakamura
Raman cell imaging with boron cluster molecules conjugated with biomolecules
RSC Advances, 2019, 9, 23973–23978.

Intellectual property:

Patents:

  1. Schinazi R.F., Fulcrand-El Kattan G., Leśnikowski Z.J., Nucleosides and oligonucleotides containing boron clusters, U.S. Patent No. 6,180,766 (30.01.2001).
  1. Leśnikowski Z.J., Przepiórkiewicz, M., Paradowska, E., Cieślikowski, T. Oligonucleotide, its use and application for detection of cytomegalovirus (HCMV) Polish Patent Office, Patent Number: P.189683 (14.01.2005).
  1. Zbigniew J. Leśnikowski, Agnieszka Olejniczak, Nucleoside derivatives, modified oligonucleotide, method for their synthesis and application thereof, Polish Patent Office, Patent Number: P 359949 (22-06-2010).
  1. Zbigniew J. Leśnikowski and Agnieszka Olejniczak, Nucleoside Derivative, Modified Oligonucleotide, Method for Their Synthesis And Applications Thereof, U.S. Patent No. 8,026,348 issued on September 27, 2011.
  1. Janusz Boratyński, Tomasz Goszczyñski, Konrad Kowalski, Zbigniew Leśnikowski
    Sposób otrzymywania koniugatów białko-klaster boru w fazie stałej
    Urząd Patentowy RP, Nr P. 398 379. (14.12.2015)
  1. Janusz Boratyñski, Tomasz Goszczyñski, Konrad Kowalski, Zbigniew Leśnikowski
    Sposób otrzymywania koniugatów białko-klaster boru w roztworze, Urząd Patentowy RP, Nr P. 398 380. (21.06.2016)
  1. Edyta Paradowska, Mirosława Studzińska, Zbigniew Leśnikowski, Patrycja Suski, Sposób badania aktywności przeciwwirusowej związków względem HCMV, Urząd Patentowy RP, Nr P.394 695 (15.12.2017)
  1. Jerzy Radecki, Hanna Radecka, Iwona Grabowska, Agnieszka Sirko, Anna Góra-Sochacka, Zbigniew Leśnikowski, Agnieszka Olejniczak, Bioczujnik elektrochemiczny oraz zastosowanie bioczujnika, Urząd Patentowy RP, Nr P.222314 (29.07.2016).
  1. Agnieszka B. Olejniczak, Zbigniew J. Leśnikowski, Daria Różycka, Pochodne kwasu 6-aminopenicylanowego (6-APA), związki pośrednie oraz zastosowanie medyczne pochodnych kwasu 6-aminopenicylanowego. Urząd Patentowy RP, patent Nr. 234565, 30.04.2020
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