Lista wybranych publikacji


Wybrane publikacje 2011-2017

 

Rok 2017

 

  1. Studzińska Mirosława, Jabłońska Agnieszka, Wiśniewska-Ligier Małgorzata, Nowakowska Dorota, Gaj Zuzanna, Leśnikowski Zbigniew J., Woźniakowska-Gęsicka Teresa, Wilczyński Jan, Paradowska Edyta. Association of TLR3 L412F Polymorphism with Cytomegalovirus Infection in Children. PLoS One. 2017 ,12(1):e0169420

  2. Wujcicka Wioletta, Paradowska Edyta, Studzińska Mirosława, Wilczyński Jan, Nowakowska Dorota. TLR2 2258 G>A single nucleotide polymorphism and the risk of congenital infection with human cytomegalovirus. Virol J. 2017, 14(1):12.

 

Rok 2016

 

  1. Julia Laskova, Alexandra Kozlova, Magdalena Białek-Pietras, Mirosława Studzińska, Edyta Paradowska, Vladimir Bregadze, Zbigniew J. Leśnikowski, Andrey Semioshkin, Reactions of closo-dodecaborate amines. Towards novel bis-(closododecaborates) and closo-dodecaborate conjugates with lipids and non-natural Nucleosides.
    J. Organomet. Chem., 2016, 807, 29-35.

  2. Edyta Paradowska, Agnieszka Jabłońska, Mirosława Studzińska, Katarzyna Skowrońska, Patrycja Suski, Małgorzata Wiśniewska-Ligier, Teresa Woźniakowska-Gęsicka, Dorota Nowakowska, Zuzanna Gaj, Jan Wilczyński, Zbigniew J. Leśnikowski. TLR9 -1486T/C and 2848C/T SNPs Are Associated with Human Cytomegalovirus Infection in Infants.
    PLoS ONE, 2016, 11: e0154100.

  3. Zbigniew J. Leśnikowski. Recent developments with boron as a platform for novel drug design.
    Exp. Op. Drug Disc., 2016, 11, 569-578.

  4. Zbigniew J. Leśnikowski.Challenges and Opportunities for the Application of Boron Clusters in Drug Design.
    J. Med. Chem. 2016, 59, 7738-7758.

  5. Anna Adamska, Anna Rumijowska-Galewicz, Anna Ruszczynska, Mirosława Studzińska, Agnieszka Jabłońska, Edyta Paradowska, Ewa Bulska, Helene Munier-Lehmann, Jarosław Dziadek, Zbigniew J. Leśnikowski, Agnieszka B. Olejniczak. Anti-mycobacterial activity of thymine derivatives bearing boron clusters.
    Eur. J. Med. Chem., 2016, 121, 71-81.

  6. Jolanta D. Żołnierczyk, Agnieszka B. Olejniczak,  Adam J. Mieczkowski, Jerzy Z. Błoński,  Zofia M. Kiliańska,  Tadeusz Robak  and Zbigniew J. Leśnikowski, In vitro antileukemic activity of novel adenosine derivatives bearing boron cluster modification.
    Bioorg. Med. Chem., 2016, 24, 5076–5087.

 

Rok 2015

 

  1. Edyta Paradowska, Mirosława Studzińska, Patrycja Suski, Beata Kasztelewicz, Małgorzata Wiśniewska-Ligier, Barbara Zawilińska, Zuzanna Gaj, Dorota Nowakowska. Human cytomegalovirus UL55, UL144, and US28 genotype distribution in infants infected congenitally or postnatally.
    J Med Virol, 2015, 87 (10), 1737-1748. DOI 10.1002/jmv.24222


  2. Konrad Kowalski, Tomasz Goszczynski, Zbigniew J. Lesnikowski, Janusz Boratyński. Synthesis of lysozyme-metallacarborane conjugates and the effect of boron cluster modification on protein structure and function.
    ChemBioChem, 2015, 16, 424-431.


  3. Tomasz M. Goszczyński, Konrad Kowalski, Zbigniew J. Leśnikowski, Janusz Boratyński, Solid State, Thermal Synthesis of Site-Specific Protein–Boron Cluster Conjugates and Their Physicochemical and Biochemical Properties.
    BBA - General Subjects, 2015, 1850, 411-418.


  4. Michał Matuszewski, Agnieszka Kiliszek, Wojciech Rypniewski, Zbigniew J. Leśnikowski, Agnieszka B. Olejniczak.
    Nucleoside bearing boron clusters and their phosphoramidites – building blocks for modified oligonucleotide synthesis.
    New J Chem, 2015, 39, 1202-1221.


  5. I. Lobanova, I. Kosenko, J. Laskova, I. Ananyev, A. Druzina, I. Godovikov, V. Bregadze, Shicheng Qi, Z.J. Leśnikowski and A. Semioshkin.
    Synthesis and structure of 8-tetrahydrofuronium and 8-tetrahydropyronium derivatives of iron bis(dicarbollide)(-I) and their ring cleavage reactions. Design of novel ferracarborane ligands and nucleoside conjugates.
    Dalton Trans., 2015, 44, 1571-1584.


  6. Magdalena Rycel, Wioletta Wujcicka, Barbara Zawilińska, Edyta Paradowska, Patrycja Suski, Zuzanna Gaj, Jan Wilczyński, Zbigniew J. Leśnikowski, Dorota Nowakowska.
    Mixed infections with distinct cytomegalovirus glycoprotein B genotypes in Polish pregnant women, foetuses, and newborns.
    Eur J Clin Microbiol Infect Dis, 2015, 34, 585–591. DOI: 10.1007/s10096-014-2266-9


  7. Anna Lewandowska-Polak, Małgorzata Brauncajs, Edyta Paradowska, Marzanna Jarzębska , Marcin Kurowski, Sylwia Moskwa, Zbigniew J. Leśnikowski, Marek L. Kowalski.
    Human parainfluenza virus type 3 (HPIV3) induces production of IFN-gamma and RANTES in human nasal epithelial cells (HNECs).
    Journal of Inflammation (United Kingdom), 2015, 12, 16. DOI: 10.1186/s12950-015-0054-7


  8. Wioletta Wujcicka, Edyta Paradowska, Mirosława Studzińska, Zuzanna Gaj, Jan Wilczyński, Zbigniew Leśnikowski, Dorota Nowakowska.
    TLR9 2848 GA Heterozygotic Status Possibly Predisposes Fetuses and Newborns to Congenital Infection with Human Cytomegalovirus.
    PLOS ONE, 2015, 10(4), e0122831. DOI:10.1371/journal.pone.0122831


  9. Magdalena Białek-Pietras, Agnieszka B. Olejniczak, Edyta Paradowska, Mirosława Studzińska, Patrycja Suski, Agnieszka Jabłońska, Zbigniew J. Leśnikowski
    Synthesis and in vitro antiviral activity of lipophilic pyrimidine nucleoside/carborane conjugates.
    J. Organomet. Chem., DOI:10.1016/j.jorganchem.2015.07.002


  10. Slawomir Janczak, Agnieszka Olejniczak, Sandra Balabańska, Marcin K. Chmielewski, Marius Lupu, Clara Viñas, Zbigniew J. Lesnikowski.
    The boron clusters as a platform for new materials: synthesis of functionalized o-carborane (C2B10H12) derivatives incorporating DNA fragments.
    Chemistry - A European Journal, 2015, 21, 15118-15122.

 

Rok 2014

 

  1. Paradowska E., Jabłońska A., Płóciennikowska A., Studzińska M., Suski P., Wiśniewska-Ligier M., Dzierżanowska-Fangrat K., Kasztelewicz B., Woźniakowska-Gęsicka T., Leśnikowski Z.J.
    Cytomegalovirus alpha-chemokine genotypes are associated with clinical manifestations in children with congenital or postnatal infections.
    Virology, 2014, 462-463C:207-217.


  2. Paradowska E., Jabłońska A., Studzińska M., Kasztelewicz B., Zawilińska B., Wiśniewska-Ligier M., Dzierżanowska-Fangrat K., Woźniakowska-Gęsicka T., Kosz-Vnenchak M., Leśnikowski Z.J.
    Cytomegalovirus glycoprotein H genotype distribution and the relationship with hearing loss in children.
    Journal of Medical Virology, 2014, 86, 1421-1427.


  3. Jabłońska A., Paradowska E., Studzińska M., Suski P., Nowakowska D., Wiśniewska-Ligier M., Woźniakowska-Gęsicka T., Wilczyński J., Leśnikowski Z.J.
    Relationship between Toll-like receptor 2 Arg677Trp and Arg753Gln and Toll-like receptor 4 Asp299Gly polymorphisms and cytomegalovirus infection.
    International Journal of Infectious Diseases, 2014,25: e11–e15.


  4. Gaj Z., Wilczyński J., Nowakowska-Głąb A., Boakye-Agyeman F., Paradowska E., Leśnikowski Z.J. Nowakowska D.
    Decrease in 3-nitrotyrosine in the amniotic fluid of women with cytomegalovirus infection.
    Journal of Obstetrics and Gynaecology, 2014,34, 251-254.


  5. Rycel M., Gaj Z., Wilczyński J., Paradowska E., Studzińska M., Suski P., Nowakowska D. Ocena związku poziomu wiremii HCMV u matki z przebiegiem ciąży i stanem urodzeniowym noworodków.
    Ginekologia Polska,2014, 84, 1005-1011.


  6. Ilinova A., Semioshkin A, Lobanova I., Bregadze V.I., Mironov A.F., Paradowska E., Studziska M., Jabłońska A, Białek-Pietras M., Zbigniew J. Leśnikowski.
    Synthesis, cytotoxicity and antiviral activity studies of the conjugates of cobalt bis(1,2-dicarbollide)(-I) with 5-ethynyl-2'-deoxyuridine and its cyclic derivatives.
    Tetrahedron, 2014, 70, 5704-5710.


  7. Grabowska I., Stachyra A., Góra-Sochacka A., Sirko A., Olejniczak A.B., Leśnikowski Z.J., Radecki J., Radecka H.
    DNA probe modified with 3-iron bis(dicarbollide) for electrochemical determination of DNA sequence of Avian Influenza Virus H5N1.
    Biosensors and Bioelectronics, 2014, 51, 170-176.


  8. Akiyama T., Saito K., JanczakS., Leśnikowski Z.J.
    Phosphoric Acid-Bridged Cobalt bis(Dicarbollide) Ion as an Efficient Reducing Agent for the Organocatalytic Hydrogenation of Ketimines.
    SYNLETT, 2014,795-798.


  9. Bednarska K., Olejniczak A.B., Klink M., Sułowska Z., Leśnikowski Z.J.
    Modulation of human neutrophil activity by adenosine modified with a carborane pharmacophore.
    Bioorganic & Medicinal Chemical Letters, 2014, 24, 3073-3078.


  10. Jabłońska A., Paradowska E.
    Role of the RIG-I-like receptors in antiviral response.
    Postepy Higieny i Medycyny Doswiadczalnej, 2014, 68, 541-556 (in polish).

 

Rok 2013

 

  1. Paradowska E., Jabłońska A., Studzińska M., Suski P., Kasztelewicz B., Zawilińska B., Wiśniewska-Ligier M., Dzierżanowska-Fangrat K., Woźniakowska-Gęsicka T., Czech-Kowalska J., Lipka B., Kornacka M., Pawlik D., Tomasik T., Kosz-Vnenchak M., Leśnikowski Z.J.
    Cytomegalovirus gN and gH genotypes distribution and clinical sequels in infants.
    Journal of Clinical Virology, 2013, 58, 271-275.


  2. Olejniczak A.B., Adamska A.M., Paradowska E., Studzińska M., Suski P., Leśnikowski Z.J.
    Modification of selected anti-HCMV drugs with lipophilic boron cluster modulator.
    Acta Poloniae Pharmaceutica Drug Research,2013, 70 (3), 489-504.


  3. Semioshkin A., Ilinova A., Lobanova I., Bregadze V., Paradowska E., Studzińska M., Jabłońska A., Lesnikowski Z.J.
    Synthesis of the first conjugates of 5-ethynyl-2'-deoxyuridine with closo-dodecaborate and cobalt-bis-dicarbollide boron clusters.
    Tetrahedron, 2013, 69, 8034-8041.


  4. Białek-Pietras M., Olejniczak A.B., Tachikawa S., Nakamura H.,, Leśnikowski Z.J.
    Towards new boron carriers for boron neutron capture therapy: metallacarboranes bearing cobalt, iron and chromium and their cholesterol conjugates.
    Bioorganic & Medicinal Chemistry, 2013,21, 1136-1142.


  5. Kwiatkowska A., Sobczak M., Mikolajczyk B., Janczak S., Olejniczak A.B., Sochacki M., Lesnikowski Z.J.,, Nawrot B.
    siRNAs modified with boron cluster and their physicochemical and biological characterization.
    Bioconjugate Chemistry, 2013, 24, 1017-1026.


  6. Olejniczak A.B., Kierzek R., Wickstrom E., Leśnikowski Z.J.. Synthesis, physicochemical and biochemical studies of anti-IRS-1 oligonucleotides containing carborane and/or metallacarborane modification.
    Journal of Organometallic Chemistry, 2013, 747, 201-210.


  7. Wojtczak B.A., Olejniczak A.B., Wang L., Eriksson S., Leśnikowski Z.J..
    Phosphorylation of nucleoside-metallacarborane and carborane conjugates by nucleoside kinases.
    Nucl. Nucl. Nucl. Acids, 2013, 32:571–588.

 

Rok 2012

 

  1. Paradowska E., Studzińska M., Nowakowska D., Wilczyński J., Rycel M., Suski P., Gaj Z., Kaczmarek B., Zbróg Z., Leśnikowski Z.J.
    Distribution of UL144, US28 and UL55 genotypes in Polish newborns with congenital cytomegalovirus infections.
    European Journal of Clinical Microbiology and Infectious Diseases, 2012, 31, 1335-1345.

  2. R. Ziółkowski, A.B. Olejniczak, Ł. Górski, J. Janusik, Z.J. Leśnikowski, E. Malinowska. Electrochemical detection of DNA hybridization using metallacarborane unit.
    Bioelectrochemistry, 2012, 87, 78-83.

  3. Zwoliński K.M., Leśnikowski Z.J.
    Libraries of chemical compounds.
    Wiadomosci Chemiczne, 2012, 66, 742-765 (in polish).

  4. Bednarska K., Olejniczak A.B., Piskała A., Klink M., Sułowska Z., Leśnikowski Z.J..
    Effect of adenosine modified with a boron cluster pharmacophore on reactive oxygen species production by human neutrophils.
    Bioorganic & Medicinal Chemistry, 2012, 20, 6621-6629.

 

Rok 2011

 

  1. Szala A., Paradowska E., Nowakowska D., Świerzko A.S., Dzierżanowska-Fangrat K., Sokołowska A., Studzińska M., Gaj Z., Suski P., Kasztelewicz B., Wilczyński J., Cedzyński M. Mannan-binding lectin-2 (MBL2) gene polymorphisms in prenatal and perinatal cytomegalovirus infections.
    Molecular Immunology, 2011, 48, 2203-2206.

  2. Semioshkin A., Laskova J., Ilinova A., Bregadze V., Lesnikowski Z.J..
    Reactions of oxonium derivatives of [B12H12]2- with sulphur nucleopliles. Synthesis of novel B12-based mercaptanes, sulfides and nucleosides.
    Journal of Organometallic Chemistry, 2011, 696, 539-543.

  3. Semioshkin A., Bregadze V., Godovikov I., Ilinova A., Lobanova I., Lesnikowski Z.J..
    A convenient approach towards boron cluster modifications with adenosine and 2'-deoxyadenosine.
    Journal of Organometallic Chemistry, 2011, 696, 3750-3755.

  4. Lesnikowski, Z. J.
    New Opportunities in Boron Chemistry for Medical Applications.
    In Boron Sciences. New technologies and Applications, Hosmane, N.S., Ed.; CRC Press., 2011; Boca Raton, FL, pp 3-19.

 

Ochrona własności intelektualnej:

 

Pateny:

 

  1. Schinazi R.F., Fulcrand-El Kattan G., Leśnikowski Z.J., Nucleosides and oligonucleotides containing boron clusters, U.S. Patent No. 6,180,766 (30.01.2001).

  2. Leśnikowski Z.J., Przepiórkiewicz, M., Paradowska, E., Cieślikowski, T. Oligonucleotide, its use and application for detection of cytomegalovirus (HCMV) Polish Patent Office, Patent Number: P.189683 (14.01.2005).

  3. Zbigniew J. Leśnikowski, Agnieszka Olejniczak, Nucleoside derivatives, modified oligonucleotide, method for their synthesis and application thereof, Polish Patent Office, Patent Number: P 359949 (22-06-2010).

  4. Zbigniew J. Leśnikowski and Agnieszka Olejniczak, Nucleoside Derivative, Modified Oligonucleotide, Method for Their Synthesis And Applications Thereof, U.S. Patent No. 8,026,348 issued on September 27, 2011.

 

Zgłoszenia patentowe:

 

  1. Zbigniew J. Leśnikowski, Agnieszka Olejniczak, Application of carboranes and metallacarboranes and their derivatives, Polish Patent Office, application number, P 360228A1 (20-05-2003).

  2. Zbigniew J. Leśnikowski, Agnieszka Olejniczak, Nucleoside derivative, modified oligonucleotide, metod for their synthesis and application thereof, international application numer: PCT/PL04/00030 (30-04-2004).

  3. Jerzy Radecki, Hanna Radecka, Iwona Grabowska, Agnieszka Sirko, Anna Góra-Sochacka, Zbigniew Leśnikowski, Agnieszka Olejniczak, Electrochemical biosensor and application thereof, Polish Patent Office, application numer: P.40033 (2012-08-10).

  4. Edyta Paradowska, Mirosława Studzińska, Zbigniew J. Leśnikowski, Patrycja Suski, A metod for testing of chemical compounds' activity against hCMV, Polish Patent Office, application numer: P 394 695 (29.04 2011).

  5. Zbigniew J. Leśnikowski, Agnieszka Olejniczak, Edyta Paradowska, Mirosława Studzińska, Antiviral drug derivative, Polish Patent Office, application numer P.394 696 (29.04.2011).

  6. Zbigniew J. Leśnikowski, Agnieszka Olejniczak, Anna Adamska, Edyta Paradowska, Mirosława Studzińska, Antiviral drug derivative, international application numer: PZ/1199/AW,PCT/PL2011/050012 (29.04.2011).

  7. Janusz Boratyński (IIiTD PAN), Tomasz Goszczyński (IIiTD PAN), Konrad Kowalski (IIiTD PAN), Zbigniew J. Leśnikowski (IBM PAN), Method for synthesis of protein-boron cluster conjugastes in solid phase, Polish Patent Office, application numer:P 398 379 (09.03.2012).

  8. Janusz Boratyński (IIiTD PAN), Tomasz Goszczyński (IIiTD PAN), Konrad Kowalski (IIiTD PAN), Zbigniew J. Leśnikowski (IBM PAN), Method for synthesis of protein-boron cluster conjugastes in solution, Polish Patent Office, application numer:P 398 380 (09.03.2012).

  9. Zbigniew Leśnikowski (IBM PAN), Agnieszka Olejniczak (IBM PAN), Zofia Kiliańska (Uniwersytet Łódzki), Jolanta Żołnierczyk (Uniwersytet Łódzki), Tadeusz Robak (Uniwersytet Medyczny w Łodzi), Adam Mieczkowski (IBB PAN), A nucleoside derivative for use as a drug, particularly for the treatment of chronic lymphocytic leukemia, Polish Patent Office, application numer: PL 408063 (29.04. 2014).

  10. Zbigniew Leśnikowski (IBM PAN), Agnieszka Olejniczak (IBM PAN), Zofia Kiliańska (Uniwersytet Łódzki), Jolanta Żołnierczyk (Uniwersytet Łódzki), Tadeusz Robak (Uniwersytet Medyczny w Łodzi), Adam Mieczkowski (IBB PAN), A nucleoside derivative for use as a drug, particularly for the treatment of chronic lymphocytic leukemia, international application numer: RM2014A/000459 (05.08.2014).