Instytut Biologii Medycznej PAN

Labs > Medicinal Chemistry > Selected publications

Selected publications

List of selected publications


Selected papers 2017-2021

 

Year 2021

Storm Hassell-Hart, Sarah Picaud, Raphael Lengacher, Joshua Csucker, Regis Millet, Gilles Gasser, Roger Alberto, Hannah Maple, Robert Felix, Zbigniew J. Leśnikowski, Helen J. S. Stewart, Timothy J. Chevassut, Simon Morley, Panagis Filippakopoulos, John Spencer,

Probing BRD Inhibition Substituent Effects in Bulky Analogues of (+)-JQ1.

Helvetica Chimica Acta., 2021, 104, e2000214, DOI: 10.1002/hlca.202000214

 

Damian Kaniowski, Katarzyna Ebenryter-Olbińska, Katarzyna Kulik,
Justyna Suwara, Wojciech Cypryk, Agata Jakóbik-Kolon, Zbigniew Leśnikowski, Barbara Nawrot

Composites of nucleic acids and boron clusters (C2B10H12) as
functional nanoparticles for downregulation of EGFR oncogene in cancer cells

International Journal of Molecular Sciences, 2021, 22, 4863. https://doi.org/10.3390/ijms22094863

 

David Kodr,  Cansu Pinar Yenice, Anna Simonova, Dijana Pavlović Saftić, Radek Pohl, Veronika Sýkorová, Mayreli Ortiz, Luděk Havran, Miroslav Fojta, Zbigniew J. Lesnikowski, Ciara K. O'Sullivan, and Michal Hocek

Carborane- or Metallacarborane-Linked Nucleotides for Redox Labelling. Orthogonal Multipotential Coding of all Four DNA Bases for Electrochemical Analysis and Sequencing

Journal of American Chemical Society, 2021, accepted

 

Year 2020

Dijana Saftić, Mirosława Studzińska, Edyta Paradowska, Ivo Piantanida, Goran Baranović, Magdalena Białek-Pietras and Zbigniew J. Leśnikowski

Comparative study of the effects of ortho-, meta- and para-carboranes (C2B10H12) on the physicochemical properties, cytotoxicity and antiviral activity of uridine and 2’-deoxyuridine boron cluster conjugate.

Bioorganic Chemistry, 2020, 94, 103466. doi.org/10.1016/j.bioorg.2019.103466

 

Damian Kaniowski, Katarzyna Ebenryter-Olbinska, Katarzyna Kulik, Slawomir Janczak, Anna Maciaszek, Katarzyna Bednarska-Szczepaniak, Barbara Nawrot and Zbigniew Lesnikowski

Boron Clusters as a Platform for New Materials: Composites of Nucleic Acids and Oligofunctionalized Carboranes (C2B10H12) and their Assembly into Functional Nanoparticles Nanoscale, 2020, 12, 103–114 DOI: 10.1039/C9NR06550D

 

Damian Kaniowski, Katarzyna Kulik, Katarzyna Ebenryter-Olbińska, Ewelina Wielgus,

Zbigniew Leśnikowski  and Barbara Nawrot

Metallacarborane Complex Boosts the Rate of DNA Oligonucleotide Hydrolysis in the Reaction Catalyzed by Snake Venom Phosphodiesterase

Biomolecules 2020, 10, 718; doi:10.3390/biom10050718.

 

Agnieszka Jabłonska, Anna S. Swierzko, Mirosława Studzinska, Patrycja Suski, Jarosław Kalinka, Zbigniew J. Lesnikowski, Maciej Cedzynski, Edyta Paradowska

Insight into the expression of RIG-I-like receptors in human third trimester placentas following ex vivo cytomegalovirus or vesicular stomatitis virus infection

Molecular Immunology, 2020, 126, 143–152.

 

 

 

Zbigniew J. Leśnikowski

What are the current challenges with the application of boron clusters to drug design?

Expert Opinion on Drug Discovery, 2020, DOI: 10.1080/17460441.2021.1867531

 

Year 2019

P. Brennecke, D. Rasina, O. Aubi, (…) Z. Lesnikowski and forty other co-authors

EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology

SLAS Discovery, 2019, 1–16.

 

Daria Różycka, Zbigniew J. Lesnikowski, Agnieszka B. Olejniczak

Synthesis of boron cluster analogs of penicillin and their antibacterial activity

Journal of Organometallic Chemistry, 2019, 881  19e24

 

Adam Mieczkowski,  Aleksandra Kierozalska, Magdalena Białek-Pietras, Tomasz M. Goszczyński, Slawomir Janczak, Agnieszka B. Olejniczak, Mirosława Studzińska, Edyta Paradowska and Zbigniew J. Leśnikowski

Comparative study of inorganic, boron-rich cluster and organic, phenyl adenosine modifications: Synthesis and properties

Future Medicinal Chemistry, 2019,11, 1267-1284. doi: 10.4155/fmc-2018-0517

 

Carla Sardo, Sławomir Janczak and Zbigniew J. Leśniowski

Unusual resistance of cobalt bis dicarbollide phosphate and phosphorothioate bridged esters towards alkaline hydrolysis: The "metallacarborane effect“

Journal of Organometallic Chemistry, 2019, 896, 70-76.

 

Masahito Mochizuki, Shinichi Sato, Syifa Asatyas, Zbigniew J. Lesnikowski, Tomohiro Hayashi and Hiroyuki Nakamura

Raman cell imaging with boron cluster molecules conjugated with biomolecules

RSC Advances, 2019, 9, 23973–23978.

 

Year 2018

Magdalena Białek-Pietras, Agnieszka B. Olejniczak, Edyta Paradowska, Mirosława Studzińska, Agnieszka Jabłońska and Zbigniew J. Leśnikowski

Synthesis, susceptibility to enzymatic phosphorylation, cytotoxicity and in vitro antiviral activity of lipophilic pyrimidine nucleoside/carborane conjugates

Journal of Organometallic Chemistry, 2018, 865, 166-172. doi.org/10.1016/j.jorganchem.2018.03.026 

 

Anna Adamska-Bartłomiejczyk, Katarzyna Bednarska, Magdalena Białek-Pietras, Zofia M. Kiliańska, Adam Mieczkowski, Agnieszka B. Olejniczak, Edyta Paradowska, Mirosława Studzińska, Zofia Sułowska, Jolanta D. Żołnierczyk and Zbigniew J. Lesnikowski

Boron cluster modifications with antiviral, anticancer and modulation of purinergic receptors activities based on nucleoside structure

In “Boron-Based Compounds: Potential and Emerging Applications in Medicine”, (E-M. Hey-Hawkins, C. Vinas-Teixidor, Eds.,), John Wiley & Sons, Inc., Chapter 1.2, pp 20-34, 2018.

 

Marian Vincenzi, Katarzyna Bednarska and Zbigniew J. Leśnikowsk

Comparative study of carborane- and phenyl-modified adenosine derivatives as ligands for the A2A and A3 adenosine receptors based on a rigid in silico docking and radioligand replacement assay

Molecules 2018, 23, 1846; doi:10.3390/molecules23081846

 

 

 

 

Agnieszka B. Olejniczak and Zbigniew J. Lesnikowski

Boron Clusters as Redox Labels for Nucleosides and Nucleic Acids

In “Handbook of Boron Science with Applications in Organometallics, Catalysis, Materials and Medicine”, Vol. 4 Boron in Medicine (Narayan S. Hosmane, Robert Eagling, Eds.,),World Scientific, NJ., Chapter 1, pp 1-13, 2018.

 

Agnieszka B. Olejniczak, Barbara Nawrot and Zbigniew J. Lesnikowski

DNA Modified with Boron–Metal Cluster Complexes [M(C2B9H11)2]—Synthesis, Properties, and Application

International Journal of Molecular Sciences 2018, 19, 3501; doi:10.3390/ijms19113501.

 

Dijana Saftić, Biserka Žinić, Ljubica Glavaš-Obrovac, Mirosława Studzińska, Edyta Paradowska, Zbigniew J. Leśnikowski

Synthesis and in vitro evaluation of antiviral and cytostatic properties of novel 8-triazolyl acyclovir derivatives

Nucleosides, Nucleotides and Nucleic Acids, 2018, 37, 397-414. DOI: 10.1080/15257770.2018.1485932

 

Year 2017

Mirosława Studzińska, Agnieszka Jabłońska, Małgorzata Wiśniewska-Ligier, Dorota Nowakowska, Zuzanna Gaj, Zbigniew J. Leśnikowski, Teresa Woźniakowska- Gęsicka, Jan Wilczyński, Edyta Paradowska

Association of TLR3 L412F Polymorphism with Cytomegalovirus Infection in Children

PLoS ONE, 12, 2017: e0169420. doi:10.1371/journal.pone.0169420,

 

M.L. Kowalski, A. Wardzynska, M. Studzinska, M. Pawelczyk, Z.J. Lesnikowski, E. Paradowska

Cytomegalovirus DNA is highly prevalent in the blond of patients with asthma and is associated with age and asthma traits

Allergy, 2017, 72, 2035-2038.

 

Damian Kaniowski, Katarzyna Ebenryter-Olbinska, Milena Sobczak, Błazej Wojtczak, Sławomir Janczak, Zbigniew J. Lesnikowski, and Barbara Nawrot

High Boron-loaded DNA-Oligomers as Potential Boron Neutron Capture Therapy and Antisense Oligonucleotide Dual-Action Anticancer Agents

Molecules 2017, 22, 1393; doi:10.3390/molecules22091393,

 

Tomasz M. Goszczyński, Krzysztof Fink, Konrad Kowalski, Zbigniew J. Leśnikowski,  Janusz Boratyński

Interactions of Boron Clusters and their Derivatives with Serum Albumin

Scientific Reports, | 7: 9800 | DOI:10.1038/s41598-017-10314-0,

 

Katarzyna Ebenryter-Olbińska, Damian Kaniowski, Milena Sobczak, Błażej A.Wojtczak, Sławomir Janczak, Ewelina Wielgus, Barbara Nawrot and Zbigniew J. Leśnikowski

Versatile method for the site specific modification of DNA with boron clusters – Anti-EGFR antisense oligonucleotide case

Chemistry - European Journal, 2017, 23, 16535-16546,

 

Irina Kosenko, Ivan Ananyev, Anna Druzina, Ivan Godovikov, Julia Laskova, Vladimir Bregadze, Miroslawa Studzinska, Edyta Paradowska, Zbigniew J. Lesnikowski, Andrey Semioshkin

Disubstituted cobalt bis(1,2-dicarbollide)(-I) terminal alkynes: Synthesis, reactivity in the Sonogashira reaction and application in the synthesis of cobalt bis(1,2-dicarbollide)(-I) nucleoside conjugates

Journal of Organometallic Chemistry, 2017, 849-850, 142-149. http://dx.doi.org/10.1016/j.jorganchem.2017.02.030.

 

Jana Balintová, Anna Simonova, Magdalena Białek-Pietras, Agnieszka Olejniczak, Zbigniew J. Lesnikowski, Michal Hocek

Carborane-linked 2'-deoxyuridine 5'-O-triphosphateas building block for polymerase synthesis of carborane-modified DNA.

Bioorganic and Medicinal Chemistry Letters, 2017, 27, 4786-4788.

 

Intellectual property:

Patents:

  1. Schinazi R.F., Fulcrand-El Kattan G., Leśnikowski Z.J., Nucleosides and oligonucleotides containing boron clusters, U.S. Patent No. 6,180,766 (30.01.2001).

 

  1. Leśnikowski Z.J., Przepiórkiewicz, M., Paradowska, E., Cieślikowski, T. Oligonucleotide, its use and application for detection of cytomegalovirus (HCMV) Polish Patent Office, Patent Number: P.189683 (14.01.2005).

 

  1. Zbigniew J. Leśnikowski, Agnieszka Olejniczak, Nucleoside derivatives, modified oligonucleotide, method for their synthesis and application thereof, Polish Patent Office, Patent Number: P 359949 (22-06-2010).

 

  1. Zbigniew J. Leśnikowski and Agnieszka Olejniczak, Nucleoside Derivative, Modified Oligonucleotide, Method for Their Synthesis And Applications Thereof, U.S. Patent No. 8,026,348 issued on September 27, 2011.

 

5.     Janusz Boratyński, Tomasz Goszczyński, Konrad Kowalski, Zbigniew Leœnikowski

Method of obtaining protein-boron cluster conjugates in solid phase, Polish Patent Office, Nr P. 398 379. (14.12.2015)

 

6.     Janusz Boratyński, Tomasz Goszczyński, Konrad Kowalski, Zbigniew Leśnikowski

Method of obtaining protein-boron cluster conjugates in solution, Polish Patent Office, Nr P. 398 380. (21.06.2016)

 

7.     Edyta Paradowska, Mirosława Studzińska, Zbigniew Leśnikowski, Patrycja Suski, A method for testing the antiviral activity of compounds against HCMV, Polish Patent Office, Nr P.394 695 (15.12.2017)

 

8.     Jerzy Radecki, Hanna Radecka, Iwona Grabowska, Agnieszka Sirko, Anna Góra-Sochacka, Zbigniew            Leœnikowski, Agnieszka Olejniczak, Electrochemical biosensor and biosensor application, Polish Patent Office, Nr P.222314 (29.07.2016).

 

9.     Agnieszka B. Olejniczak, Zbigniew J. Leśnikowski, Daria Różycka, 6-aminopenicillanic acid (6-APA) derivatives, intermediates and medical use of 6-aminopenicillanic acid derivatives, Polish Patent Office, patent Nr. 234565, 30.04.2020

 

Labs > Medicinal Chemistry > Selected publications