Instytut Biologii Medycznej PAN

Labs > Molecular and Cellular Biology > Research Topics

Research Topics


 

Ovarian cancer

The main/fundamental area of scientific interests in the Laboratory of Molecular and Cellular Biology is the determination of mechanisms responsible for ovarian cancer chemoresistance, as well as for its invasion and metastatic potential.
Ovarian cancer is one of the main cause of death from the gynecological malignancies among women worldwide. The difficulties with early diagnosis, as well as increasing resistance of ovarian cancer cells to standard chemotherapy are considered to be main reasons for this state of affairs. Although the initial response of patients to "first wave" of treatment is very promising, the recurrence of the disease can be observed in over 80% of them within 6 to 20 months after the chemotherapy. Overcoming the inefficiency of platinum based therapy is a key challenge to improve survival of ovarian cancer patients. Therefore, our research are focused mainly on finding the molecular mechanisms responsible for both intrinsic and acquired chemoresistance, what can give essential clues helpful in developing novel, targeted therapies. Secondly, our study aim to determine molecular basis of invasive character of ovarian cancer cells. Since, development of invasiveness and ability to create metastases is very often accompanied with chemoresistance it is very important to determine the mutual relations between these two phenomenon in ovarian cancer cells.

 

Mycobacterium tuberculosis

The second area of scientific interests in the Laboratory of Molecular and Cellular Biology is the evaluation and better understanding of the molecular mechanisms involved in the response of human immune cells - macrophages and neutrophils to the Mycobacterium tuberculosis(Mtb) infection.
Tuberculosis remains one of the most common diseases, being a health and social problem with the global range, not only in developing countries but also in highly developed ones, including Poland. The very important role in the emergence of host anti-tuberculosis response, play alveolar macrophages - the first line of defense in the Mtb infections. These cells have acquired various features, that protect them from the infections and eliminate the microbes. On the other hand, the mycobacteria also possess several mechanisms, that allow them not only to effectively evade being killed by macrophages but also to proliferate intracellularly. Therefore, the  main topic of our studies is to find a new virulence factors of Mtb and estimate their impact on the biological activity of human macrophages. As far as the role of macrophages in providing the first line of defense against Mtb infection is beyond doubt, the role of neutrophils is still poorly defined and constantly raises controversy. Thus, the aim of or studies is the verification of hypothesis that neutrophils can effectively help the host to response to Mtb infection.